Red Blood Cell Destruction in Autoimmune Hemolytic Anemia: Role of Complement and Potential New Targets for Therapy

Figure 3

Immune-initiated, complement-mediated erythrocyte destruction in cold agglutinin disease (CAD) and cold agglutinin syndrome (CAS). See text for further explanation. Black arrows: major pathway; gray/dotted arrows: minor pathway; CA: cold agglutinin; C: complement protein.