Red Blood Cell Destruction in Autoimmune Hemolytic Anemia: Role of Complement and Potential New Targets for Therapy

Figure 4

Immune-initiated, complement-mediated erythrocyte destruction in paroxysmal cold hemoglobinuria (PCH) showing a biphasic temperature optimum. Black arrows: major pathway (intravascular hemolysis); gray/dotted arrows: possible minor pathway; Ig: immunoglobulin; ag: antigen; ab: antibody; C: complement protein.