Red Blood Cell Destruction in Autoimmune Hemolytic Anemia: Role of Complement and Potential New Targets for Therapy

Figure 5

In vitro effects of anti-C1s antibody TNT003 on phagocytosis (black columns, left -axis) and complement fragment deposition (red columns, right -axis) on red blood cells after addition of normal human plasma and cold agglutinin-rich plasma (under blue bar), respectively. TNT003 inhibits phagocytosis and complement deposition, while anti-C5 has no impact. CAD: primary chronic cold agglutinin disease; NHS: normal human serum; IC: isotype control. Reproduced from Blood (Shi et al. 2014, [10]) with permission. Copyright: Blood, the Journal of the American Society of Hematology.

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