Red Blood Cell Destruction in Autoimmune Hemolytic Anemia: Role of Complement and Potential New Targets for Therapy

Figure 6

Future perspective on complement modulation in AIHA. Inhibitors and levels of inhibition. Black arrows: major pathway in cold agglutinin disease (CAD); gray/dotted arrows: minor pathway in CAD and major pathway in paroxysmal cold hemoglobinuria; Ig: immunoglobulin; C: complement protein; TNT003: mouse monoclonal C1s antibody; C1-INH: C1 esterase inhibitor. Previously published in Blood (Berentsen 2014, [11]), reused with permission. Copyright: Blood, the Journal of the American Society of Hematology.