The Type 7 Serotonin Receptor, 5-HT₇, Is Essential in the Mammary Gland for Regulation of Mammary Epithelial Structure and Function

Figure 2

HT7KO lactating epithelium shows dysregulated cellular architecture. (a) WT and HT7KO glands were harvested during peak lactation (day 10) and stained with hematoxylin. Black arrows indicate mononucleated cells with basal nuclear localization. Brown arrowhead indicates binucleated cells with basal nuclear localization. Black arrowheads indicate the bi- and multinucleated cells that have nonbasal nuclear localizations. (b) Quantitative analysis of the multinucleated cells represented as % of alveolar cells that are bi-/multinucleated per alveolus. The sections of glands from various mice were counted. The data is represented as mean ± SEM. The data was analyzed using -test. .

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