Ordinary and Activated Bone Grafts: Applied Classification and the Main Features

Figure 4

Scheme of intracellular cascade pathway of SDF-1 signal transduction. SDF-1: stromal-derived factor-1; R: receptor, PIP-2: phosphatidylinositol biphosphate; PLCγ: phospholipases Сγ; MAPK: mitogen-activated protein kinase; NFkВ: nucleic factor-kappa В; PI3K: phosphoinositide-3-kinase.