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BioMed Research International
Volume 2015 (2015), Article ID 371746, 15 pages
Review Article

PRP Augmentation for ACL Reconstruction

1II Orthopaedic and Traumatology Clinic, Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano No. 1/10, 40136 Bologna, Italy
2Nano-Biotechnology Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano No. 1/10, 40136 Bologna, Italy

Received 29 May 2014; Accepted 15 August 2014

Academic Editor: Tomokazu Yoshioka

Copyright © 2015 Luca Andriolo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Current research is investigating new methods to enhance tissue healing to speed up recovery time and decrease the risk of failure in Anterior Cruciate Ligament (ACL) reconstructive surgery. Biological augmentation is one of the most exploited strategies, in particular the application of Platelet Rich Plasma (PRP). Aim of the present paper is to systematically review all the preclinical and clinical papers dealing with the application of PRP as a biological enhancer during ACL reconstructive surgery. Thirty-two studies were included in the present review. The analysis of the preclinical evidence revealed that PRP was able to improve the healing potential of the tendinous graft both in terms of histological and biomechanical performance. Looking at the available clinical evidence, results were not univocal. PRP administration proved to be a safe procedure and there were some evidences that it could favor the donor site healing in case of ACL reconstruction with patellar tendon graft and positively contribute to graft maturation over time, whereas the majority of the papers did not show beneficial effects in terms of bony tunnels/graft area integration. Furthermore, PRP augmentation did not provide superior functional results at short term evaluation.