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BioMed Research International
Volume 2015, Article ID 373574, 9 pages
http://dx.doi.org/10.1155/2015/373574
Research Article

miR-193b Modulates Resistance to Doxorubicin in Human Breast Cancer Cells by Downregulating MCL-1

1Department of Surgery, The Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
2School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China
3Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province, 234 Gucui Road, Hangzhou 310012, China
4Department of Ophthalmology, Xinhua Hospital, School of Medicine, Jiaotong University, Shanghai 200092, China

Received 24 March 2015; Revised 14 May 2015; Accepted 24 May 2015

Academic Editor: Franco M. Buonaguro

Copyright © 2015 Jingpei Long et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Siegel, D. Naishadham, and A. Jemal, “Cancer statistics for Hispanics/Latinos, 2012,” CA Cancer Journal for Clinicians, vol. 62, no. 5, pp. 283–298, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. J. W. Antoon, M. D. White, E. M. Slaughter et al., “Targeting NFκB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2,” Cancer Biology & Therapy, vol. 11, no. 7, pp. 678–689, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Del Conte, C. Sessa, R. von Moos et al., “Phase I study of olaparib in combination with liposomal doxorubicin in patients with advanced solid tumours,” British Journal of Cancer, vol. 111, no. 4, pp. 651–659, 2014. View at Publisher · View at Google Scholar
  4. S. M. Attia and S. A. Bakheet, “Effect of dihydrokainate on the capacity of repair of DNA damage and apoptosis induced by doxorubicin,” Mutagenesis, vol. 28, no. 3, pp. 257–261, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Minotti, P. Menna, E. Salvatorelli, G. Cairo, and L. Gianni, “Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity,” Pharmacological Reviews, vol. 56, no. 2, pp. 185–229, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Effenberger-Neidnicht and R. Schobert, “Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin,” Cancer Chemotherapy and Pharmacology, vol. 67, no. 4, pp. 867–874, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Pramanik, N. R. Campbell, S. Das et al., “A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy,” Oncotarget, vol. 3, no. 6, pp. 640–650, 2012. View at Google Scholar · View at Scopus
  8. J. Krützfeldt, M. N. Poy, and M. Stoffel, “Strategies to determine the biological function of microRNAs,” Nature Genetics, vol. 38, no. 1, pp. S14–S19, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. A. M. Cheng, M. W. Byrom, J. Shelton, and L. P. Ford, “Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis,” Nucleic Acids Research, vol. 33, no. 4, pp. 1290–1297, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Fang, H. Shen, Y. Cao et al., “Involvement of miR-30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells,” Brazilian Journal of Medical and Biological Research, vol. 47, no. 1, pp. 60–69, 2014. View at Google Scholar · View at Scopus
  11. C. Chen, D. A. Ridzon, A. J. Broomer et al., “Real-time quantification of microRNAs by stem-loop RT-PCR,” Nucleic Acids Research, vol. 33, no. 20, article e179, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Chen, X. Zhang, C. Lentz et al., “MiR-193b regulates Mcl-1 in melanoma,” The American Journal of Pathology, vol. 179, no. 5, pp. 2162–2168, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Rivera and H. Gomez, “Chemotherapy resistance in metastatic breast cancer: the evolving role of ixabepilone,” Breast Cancer Research, vol. 12, no. 2, article S2, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Dawood, L. Austin, and M. Cristofanilli, “Cancer stem cells: implications for cancer therapy,” Oncology, vol. 28, pp. 1101–1107, 2014. View at Google Scholar
  16. A. H. Nwabo Kamdje, P. F. Seke Etet, L. Vecchio et al., “New targeted therapies for breast cancer: a focus on tumor microenvironmental signals and chemoresistant breast cancers,” World Journal of Clinical Cases, vol. 2, pp. 769–786, 2014. View at Google Scholar
  17. J. Bockhorn, R. Dalton, C. Nwachukwu et al., “MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11,” Nature Communications, vol. 4, article 1393, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Bockhorn, K. Yee, Y. F. Chang et al., “MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion,” Breast Cancer Research and Treatment, vol. 137, no. 2, pp. 373–382, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Chen, W. Tian, H. Cai, H. He, and Y. Deng, “Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer,” Medical Oncology, vol. 29, no. 4, pp. 2527–2534, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Luo, T. Zhang, H. Liu et al., “MiR-101 and Mcl-1 in non-small-cell lung cancer: expression profile and clinical significance,” Medical Oncology, vol. 29, no. 3, pp. 1681–1686, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Zhang, C. Zhao, L. Luo, H. Zhao, J. Cheng, and F. Xu, “The expression of Mcl-1 in human cervical cancer and its clinical significance,” Medical Oncology, vol. 29, no. 3, pp. 1985–1991, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Geserick, J. Wang, M. Feoktistova, and M. Leverkus, “The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin,” Cell Death and Disease, vol. 5, no. 9, Article ID e1412, 2014. View at Publisher · View at Google Scholar
  23. H. Karami, B. Baradaran, A. Esfehani, M. Sakhinia, and E. Sakhinia, “Down-regulation of Mcl-1 by small interference RNA induces apoptosis and sensitizes HL-60 leukemia cells to etoposide,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 2, pp. 629–635, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Zhang, Y. Li, X. Dong, L. Peng, and X. Nie, “MiR-363 sensitizes cisplatin-induced apoptosis targeting in Mcl-1 in breast cancer,” Medical Oncology, vol. 31, no. 12, p. 347, 2014. View at Publisher · View at Google Scholar
  25. S. Setia, B. Nehru, and S. N. Sanyal, “Celecoxib prevents colitis associated colon carcinogenesis: an upregulation of apoptosis,” Pharmacological Reports, vol. 66, no. 6, pp. 1083–1091, 2014. View at Publisher · View at Google Scholar