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BioMed Research International
Volume 2015, Article ID 379817, 9 pages
Research Article

Implication of Caspase-3 as a Common Therapeutic Target for Multineurodegenerative Disorders and Its Inhibition Using Nonpeptidyl Natural Compounds

1Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha’il, Ha’il 2440, Saudi Arabia
2Department of Biosciences, Integral University, Lucknow, Uttar Pradesh 226026, India
3School of Biotechnology, Yeungnam University, Gyeongsan 712749, Republic of Korea
4Department of Biotechnology, TERI University, New Delhi 110070, India
5Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia
6Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India

Received 4 March 2015; Revised 13 April 2015; Accepted 14 April 2015

Academic Editor: Yudong Cai

Copyright © 2015 Saif Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Caspase 3 has been targeted by several researchers to combat multi-neurodegenerative (viz., Alzheimer’s disease, Parkinson’s disease, Huntington’s diseases, and Amyotrophic lateral sclerosis) disorders. Several peptidyl inhibitors of caspase-3 have been identified. Owing to inherent difficulty in the handling and drug development from peptides, peptidyl inhibitors are not the preferred leads. Peptide based drugs result in higher drug development and handling cost. Moreover the efficiency of peptide may be compromised if the storage environment somehow deviates from the prescribed conditions. We have identified potent natural non-peptidyl inhibitors of caspase-3, effectively mimicking the interactions and binding affinity of peptidyl inhibitors.

  1. Supplementary Material