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BioMed Research International
Volume 2015, Article ID 380590, 15 pages
Research Article

Hypoxia-Inducible Factor 1 Is an Inductor of Transcription Factor Activating Protein 2 Epsilon Expression during Chondrogenic Differentiation

1Institute of Biochemistry, University of Erlangen-Nuremberg, Fahrstrasse 17, 91054 Erlangen, Germany
2Institute of Pathology, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
3Department of Trauma Surgery, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany

Received 15 February 2015; Revised 3 July 2015; Accepted 6 July 2015

Academic Editor: Martin Stoddart

Copyright © 2015 Stephan Niebler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1. Expression of matrix proteins during chondrogenic differentiation of hMSC spheroids 3-D spheroid cultures of hMSC were cultured in chondrogenic medium for a period of 28 days and mRNA was isolated at day 1, 14, 21 and 28. Expression of COL2A1 (I), ACAN (II) and MIA/CD-RAP (III) strongly increased over the course of the experiment confirming the chondrogenic differentiation process. (Data are given as means ± SEM).

  1. Supplementary Material