Study of Cytotoxic Effects of Benzonitrile Pesticides

Figure 1

Hydrolysis of dichlobenil, bromoxynil, chloroxynil, and ioxynil. The abbreviations are as follows: BAM: 2,6-dichlorobenzamide; 2,6-DCBA: 2,6-dichlorobenzoic acid; BrAM: 3,5-dibromo-4-hydroxy-benzamide; BrAC: 3,5-dibromo-4-hydroxybenzoic acid; IAM: 3,5-diiodo-4-hydroxybenzamide; and IAC: 3,5-diiodo-4-hydroxybenzoic acid. Degradation pathway utilizing enzyme nitrilase has not been previously observed for dichlobenil [3].