Study of Cytotoxic Effects of Benzonitrile Pesticides

Table 2

The inhibition coefficient (%) for 24 h exposure and (%) for 48 h exposure for reflecting effect of benzonitrile pesticides on HEK293T cells for concentrations 25 mg/L, 50 mg/L, and 100 mg/L.

Compounds	(%); 25 mg/L	(%); 25 mg/L	(%); 50 mg/L	(%); 50 mg/L	(%); 100 mg/L	(%); 100 mg/L
BRX	34 ± 1	38 ± 2	52 ± 2	59 ± 2	52 ± 2	62 ± 2
CHX	68 ± 2	70 ± 1	70 ± 3	83 ± 3	70 ± 1	82 ± 4
IOX	48 ± 1	54 ± 2	59 ± 2	62 ± 3	59 ± 2	75 ± 3
DCB	ND	ND	ND	ND	ND	ND

BRX: 3,5-dibromo-4-hydroxybenzonitrile, CHX: 3,5-dichloro-4-hydroxybenzonitrile, IOX: 3,5-diiodo-4-hydroxybenzonitrile, and DCB: 2,6-dichlorobenzonitrile; ND: cytotoxicity not observed; : the solubility of DCB in water is around 20 mg/L; therefore the inhibitions at concentrations 50 and 100 mg/L are only indicative; ±: standard deviation of 3 parallels.