Research Article
TOP2A Amplification and Overexpression in Hepatocellular Carcinoma Tissues
Table 3
Association between TOP2A overexpression and other variables.
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Variables | TOP2A overexpression† | | Negative (IHC < 10%) | Positive (IHC ≥ 10%) |
| Tissues | | | | Nontumors | 40 (100%) | 0 (0%) | <0.001 | Tumors | 11 (27.5%) | 29 (72.5%) | Age | | | | <50 | 4 (22.2%) | 14 (77.8%) | 0.499 | ≥50 | 7 (31.8%) | 15 (68.2%) | Tumor size | | | | <5 cm | 11 (78.6%) | 3 (21.4%) | 0.528 | ≥5 cm | 18 (69.2%) | 8 (30.8%) | AFP | | | | <500 | 7 (29.2%) | 17 (70.8%) | 0.919 | ≥500 | 4 (30.8%) | 9 (69.2%) | HBsAg | | | | Negative | 7 (58.3%) | 5 (41.7%) | 0.004 | Positive | 4 (14.3%) | 24 (85.7%) | TP53 expression | | | | Negative | 7 (33.3%) | 14 (66.7%) | 0.442 | Positive | 4 (22.2%) | 14 (77.8%) | Ki-67 expression | | | | <10% | 5 (55.6%) | 4 (44.4%) | 0.038 | ≥10% | 6 (20.0%) | 24 (80.0%) | CEP17 copy number | | | | <3 copy | 2 (25.0%) | 6 (75.0%) | 1.000 | ≥3 copy | 3 (25.0%) | 9 (75.0%) | TOP2A copy number | | | | <3 copy | 1 (16.7%) | 5 (83.3%) | 1.000 | ≥3 copy | 4 (28.6%) | 10 (71.4%) |
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TOP2A overexpression = TOP2A (IHC) ≥10%. †Result given as (%). Chi-square () test.
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