Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates

Table 3

Aberrant expression of myeloid markers in B-ALL and production of proinflammatory factors.

Cytokine	Expression of the myeloid markers CD13 and CD33; Median (pg/mL); IR	Expression of less than two myeloid markers; (CD13 or CD33); Median (pg/mL); IR
IL-1	46.00; 52.38	3.20; 96.39	0.009^**
IL-1	429.00; 9911.00	3.20; 13.96	0.008^**
IL-12p40	8.00; 6.80	3.00; 1.53	0.051^*
TNFα	237.00; 342.49	13.92; 22.14	0.022^*
G-CSF	37.00; 104.17	24.32; 81.19	0.558
GM-CSF	7.00; 1.69	3.20; 0.20	0.015^*
IL-7	17.00; 36.71	6.00; 12.80	0.222
INF 2	8.00; 12.80	3.20; 3.80	0.122

= 0.05; = 0.001.
Concomitant expression of CD13 and CD33. -Mann Whitney test; IR: interquartile range.