DNaseI Protects against Paraquat-Induced Acute Lung Injury and Pulmonary Fibrosis Mediated by Mitochondrial DNA

Figure 2

PQ-induced mtDNA release can enhance PBMC recruitment. (a) The chemotactic index of PBMCs but not PMNs increased after incubation with PQ-primed mtDNA-enriched supernatant. (b) The endothelial transwell fluorescein leakage assay displayed no difference in the presence of either PQ or PQ-primed mtDNA. ((c)-(d)) PQ and PQ-primed mtDNA had no statistical significant impact on endothelial cell integrity, as assessed with transendothelial monolayer electrical resistance.

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