DNaseI Protects against Paraquat-Induced Acute Lung Injury and Pulmonary Fibrosis Mediated by Mitochondrial DNA

Figure 6

DNaseI improves survival in bleomycin-induced pulmonary fibrosis mice and mtDNA was increased in BALF from CADM-ILD patients. (a) Improved survival in bleomycin-induced pulmonary fibrosis mice by i.v. administration of DNaseI ( for each group). (b) mtDNA in BALF from patients with CADM-ILD () was significantly elevated compared to controls (). Mean and SEM values were indicated.

(a)

(b)