Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma
Table 2
The 27 identified significant proteins of core network marker in both early-stage and late-stage liver cancer (intersection).
Common network marker of early-stage and late-stage liver cancer
Protein
CRV
value
Cancer_AvgExp
Control_AvgExp
APP
46.52
0.00001
13724
14041
−0.03
APP
13.87
0.00066
15083
14041
0.1
ELAVL1
22.99
0.00033
1725
1319
0.39
ELAVL1
29.69
0.00003
1791
1319
0.44
KRTAP10-5
14.73
0.00098
1
1
0.04
KRTAP10-5
20.54
0.00022
1
1
0.06
H2AFX
14.08
0.00105
608
271
1.17
H2AFX
15.43
0.00053
806
271
1.58
CDK1
13.69
0.00108
335
34
3.32
CDK1
10.31
0.00119
596
34
4.15
ESR1
12.81
0.00119
228
1537
−2.76
ESR1
34.1
0.00000
245
1537
−2.65
EZH2
12.22
0.00127
310
49
2.66
EZH2
19.05
0.00027
394
49
3
CEP250
12.05
0.00130
716
268
1.42
CEP250
16.12
0.00045
627
268
1.23
AURKB
11.41
0.00138
141
14
3.35
AURKB
7.68
0.00289
199
14
3.85
CDC20
10.89
0.00152
359
20
4.17
CDC20
8.94
0.00168
688
20
5.11
E2F1
10.54
0.00158
476
43
3.46
E2F1
8.85
0.00174
673
43
3.95
OTX1
10.29
0.00166
31
2
4.27
OTX1
6.25
0.00811
26
2
4.02
SUMO1
9.86
0.00181
2422
2982
−0.3
SUMO1
8.63
0.00188
2624
2982
−0.18
MCM4
9.76
0.00186
1308
336
1.96
MCM4
6.76
0.00535
1327
336
1.98
HGS
7.96
0.00312
2504
1167
1.1
HGS
13.9
0.00066
2441
1167
1.06
KPNA2
7.86
0.00323
1927
689
1.48
KPNA2
10.43
0.00116
2533
689
1.88
UBC
7.85
0.00323
34388
35490
−0.05
UBC
6.63
0.00591
36931
35490
0.06
SPRY2
7.5
0.00376
409
989
−1.27
SPRY2
7.17
0.00399
328
989
−1.59
TOPBP1
7.33
0.00406
799
346
1.21
TOPBP1
6.45
0.00698
875
346
1.34
SIRT7
7.11
0.00456
442
225
0.98
SIRT7
24
0.00012
456
225
1.02
WHSC1
6.67
0.00590
1217
447
1.44
WHSC1
12.06
0.00086
1369
447
1.61
MCM2
6.45
0.00666
1097
174
2.66
MCM2
8.48
0.00200
1351
174
2.96
AURKA
6.4
0.00685
570
86
2.73
AURKA
9.25
0.00154
516
86
2.58
COPS5
6.39
0.00691
1506
1184
0.35
COPS5
10
0.00128
1708
1184
0.53
PCNA
6.29
0.00749
1652
904
0.87
PCNA
15.95
0.00046
2290
904
1.34
BUB1B
6.27
0.00762
179
12
3.89
BUB1B
7.47
0.00327
320
12
4.73
DNMT1
6.02
0.00920
1376
455
1.6
DNMT1
10.63
0.00110
1383
455
1.6
There are two rows with same proteins name while the upper row represents the early stage liver cancer and the lower raw represents the late stage liver cancer. AvgExp means average expression. means fold change.