Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma

Table 3

Top 20 proteins of early-stage and late-stage liver cancer.

Protein	CRV	value	Case_AvgExp	Control_AvgExp
Top 20 proteins of early-stage liver cancer
APP	46.52		13724	14041	−0.03
KRTAP4-12	33.47		1	1	−0.17
ELAVL1	22.99	0.000329	1725	1319	0.39
KRTAP10-1	17.17	0.000756	1	1	0.04
KRTAP10-5	14.73	0.000981	1	1	0.04
H2AFX	14.08	0.001048	608	271	1.17
CDK1	13.69	0.001079	335	34	3.32
PRKDC	12.91	0.001176	4011	1684	1.25
CUL3	12.83	0.001188	1376	1606	−0.22
ESR1	12.81	0.001194	228	1537	−2.76
EZH2	12.22	0.001274	310	49	2.66
CEP250	12.05	0.001298	716	268	1.42
AURKB	11.41	0.001383	141	14	3.35
CDC20	10.89	0.001523	359	20	4.17
E2F1	10.54	0.001584	476	43	3.46
OTX1	10.29	0.001664	31	2	4.27
C19orf66	10.2	0.001688	1551	3166	−1.03
SUMO1	9.86	0.00181	2422	2982	−0.3
MCM4	9.76	0.001859	1308	336	1.96
GRB2	9.19	0.0022	3572	2608	0.45
Top 20 proteins of late stage liver cancer
ESR1	34.1		245	1537	−2.65
ELAVL1	29.69		1791	1319	0.44
UBD	28.54		20926	1781	3.55
YWHAZ	27.31		13323	6408	1.06
SIRT7	24	0.000122	456	225	1.02
HDAC5	22.07	0.000152	1696	840	1.01
KRTAP10-5	20.54	0.000224	1	1	0.06
EZH2	19.05	0.00027	394	49	3
ILF2	18.86	0.000283	4111	1737	1.24
CEP250	16.12	0.000452	627	268	1.23
PCNA	15.95	0.00046	2290	904	1.34
SUMO2	15.77	0.00049	3305	2112	0.65
H2AFX	15.43	0.000532	806	271	1.58
HSP90AB1	14.43	0.0006	30949	14629	1.08
HGS	13.9	0.000659	2441	1167	1.06
APP	13.87	0.000659	15083	14041	0.1
WHSC1	12.06	0.000861	1369	447	1.61
SETDB1	11.7	0.000912	1203	497	1.28
TRAF2	11.45	0.000938	665	277	1.26
SMARCA4	11.18	0.000992	2696	1115	1.27
SFN	11.03	0.001026	1008	55	4.19

AvgExp means average expression.
means fold change.