Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells

Figure 1

Distribution of significant SAFB1 crosslink sites within RNA segment types. (a) The proportion of cDNAs mapped to different transcript regions relative to the total number of cDNA reads revealed that the highest percentage of cDNAs was mapped to ncRNA (47.08%), followed by intergenic regions (23.24%), ORFs (19.38%), introns (5.23%), 3′ UTRs (3.83%), and 5′ UTRs (0.86%). (b) The fold enrichment of cDNA density in different types of RNAs relative to cDNA density in the whole genome highest density enrichment in ncRNAs. (c) The distribution of SAFB1 crosslink sites within different ncRNA subclasses revealed significant abundance in snRNA, Mt RNA, and snoRNA. “Other RNA” consists of pseudogenes and processed transcripts with no known ORF or function.

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