BioMed Research International

Research Article

Sporadic Creutzfeldt-Jakob Disease: Prion Pathology in Medulla Oblongata—Possible Routes of Infection and Host Susceptibility

Table 2

Quantitative neuropathological analysis of spongiosis, gliosis, and PrPSc deposits in all the examined nuclei according to the different genotypes. The main pattern of PrPSc deposits is also reported. Group 2 is the second part of the table.
Case number sCJD molecular type DMNVHNPHNIOC
SGPrPScSGPrPScSGPrPScSGPrPSc
1MM1±±−±±−−±−−±−
2MM1−±−−−−−−−−±−
3MM1+++ (syn.)±++ (syn.)−±+ (syn.)−±+ (syn.)
4MM1±±−++−++−−−−
5MM1±−−−−−−−+ (syn.)−−+ (syn.)
6MM1−−−−−−−−−−−−
7MM1±±−±±−±±−−±+ (syn.)
8MM1++−±±−−−−−−−
9MM1+++−+±−−−−−−−
10MM1±−−+±−−±−−−−
11MM2+±−−−−−−−−−−
12MM2±±−±±−−−−−−−
13MV1++++±++−±±± (syn.)−±+ (syn.)
14MV2+++ (syn.)±++ (syn.)±++ (syn.)−±+ (syn.)
15MV2±±+ (syn.)±±+ (syn.)±±+ (syn.)−++ (syn.)
16MV2−−+ (syn.)+±+ (gran., pl.-like)+++ (syn.)−±+ (syn.)
17VV2±±+ (syn., periaxo.)±±+ (syn., periaxo.)±±+ (syn., periaxo.)−±+ (syn., periaxo.)
18VV2±++±±+±+++−++
19VV2±±+−−±−−+−±+
20VV2±±+ (syn.)−±−−±+ (syn.)−±+ (syn.)
21VV2±++ (syn., gran., periaxo.)±+−±++ (syn., gran., periaxo.)−±+ (syn.)
DMNV: dorsal motor nucleus of the vagus; HN: hypoglossal nucleus; PHN: perihypoglossal nuclei; IOC: inferior olivary complex; S: spongiosis; G: gliosis; PrPSc: prion protein;syn.: synaptic; gran.: granular; periaxo.: periaxonal; pl.-like: plaque-like; −: negative; ±: mild; +: moderate; ++: severe.