Development, Characterization, and In Vitro Biological Performance of Fluconazole-Loaded Microemulsions for the Topical Treatment of Cutaneous Leishmaniasis

Table 1

Rates of the components of FLU-unloaded MEs (F1, F2, and F3) and FLU-loaded MEs (F1D, F2D, and F3D). Oil phase is cholesterol; aqueous phase is 50 M of phosphate buffer at pH 7.4; surfactant is a mixture of soy phosphatidylcholine, polyoxyl-60 hydrogenated castor oil, and sodium oleate in a proportion of 3 : 8 : 6. LTS: liquid transparent system. VTS: viscous transparent system.

	Formulations (% w/w)
	F1	F2	F3	F1D	F2D	F3D
Aqueous phase	60	50	40	60	50	40
Oil phase	10	10	10	10	10	10
Surfactant	30	40	50	30	40	50
Fluconazole	—	—	—	1	1	1
O : S ratio	0,33	0,25	0,20	0,33	0,25	0,20
Phases’ classification	LTS	VTS	VTS	LTS	VTS	VTS