BioMed Research International / 2015 / Article / Tab 3

Research Article

Development, Characterization, and In Vitro Biological Performance of Fluconazole-Loaded Microemulsions for the Topical Treatment of Cutaneous Leishmaniasis

Table 3

Compressibility, hardness, adhesion, and cohesion of FLU-unloaded MEs (F1, F2, and F3) and FLU-loaded MEs (F1D, F2D, and F3D). Each value represents the mean (± standard deviation) of three replicates at 32°C.

FormulationsMechanical parameters
Hardness (g)Compressibility (g⋅s)Adhesion (g⋅s)Cohesion

F10.327 ± 0.01927.139 ± 0.5021.085 ± 0.5960.851 ± 0.023
F1D0.189 ± 0.06526.935 ± 1.9420.854 ± 0.0890.893 ± 0.041
F23.620 ± 0.19853.784 ± 7.92329.12 ± 6.440.728 ± 0.034
F2D1.249 ± 0.164*33.904 ± 5.133*17.59 ± 5.071*0.840 ± 0.026*
F31.038 ± 0.06232.139 ± 12.2817.06 ± 1.6370.826 ± 0.088
F3D0.872 ± 0.16929.405 ± 1.87610.89 ± 3.7820.824 ± 0.062

*Significant statistical difference compared to the respective control (P < 0.05).