Development, Characterization, and In Vitro Biological Performance of Fluconazole-Loaded Microemulsions for the Topical Treatment of Cutaneous Leishmaniasis

Table 3

Compressibility, hardness, adhesion, and cohesion of FLU-unloaded MEs (F1, F2, and F3) and FLU-loaded MEs (F1D, F2D, and F3D). Each value represents the mean (± standard deviation) of three replicates at 32^°C.

Formulations	Mechanical parameters
	Hardness (g)	Compressibility (g⋅s)	Adhesion (g⋅s)	Cohesion
F1	0.327 ± 0.019	27.139 ± 0.502	1.085 ± 0.596	0.851 ± 0.023
F1D	0.189 ± 0.065	26.935 ± 1.942	0.854 ± 0.089	0.893 ± 0.041
F2	3.620 ± 0.198	53.784 ± 7.923	29.12 ± 6.44	0.728 ± 0.034
F2D	1.249 ± 0.164^*	33.904 ± 5.133^*	17.59 ± 5.071^*	0.840 ± 0.026^*
F3	1.038 ± 0.062	32.139 ± 12.28	17.06 ± 1.637	0.826 ± 0.088
F3D	0.872 ± 0.169	29.405 ± 1.876	10.89 ± 3.782	0.824 ± 0.062

 ^*Significant statistical difference compared to the respective control (P < 0.05).