Figure 3: Effect of PPSB-PEE on histopathology of heart in rats. A-group I: nondiabetic, B-group II: diabetic control (tween 80, 2%; 10 mL/kg, p.o.), and C-group III: PPSB-PEE (100 mg/kg, p.o.). (a) Nondiabetic rat showing normal architecture of heart (Grade − −). (b) Diabetic control rat heart showing massive necrosis of heart muscle fibers along with focal mass and fragmentation (+++). (c) PPSB-PEE (100 mg/kg, p.o.) treated rat heart showing minimum pathological changes, that is, swelling of myocardial fibers and focal degeneration (++). Grade −: no injury; Grade ++++: severe injury; Grade ++: moderate injury (magnification 10x).