Table 1: Effect of PPSB-PEE treatment on electrocardiographic, hemodynamic changes and LV contractile function in rats.

ParametersNondiabeticDiabetic controlPPSB-PEE (100 mg/kg)

ECGHeart rate (BPM)353.48 ± 15.12257.95 ± 32.52##338.88 ± 41.08*
QRS interval (ms)23.12 ± 5.2313.74 ± 2.03##18.23 ± 3.45*
QT interval (ms)67.26 ± 1.2491.00 ± 2.87###73.63 ± 2.02*
QTc interval (ms)131.08 ± 2.45194.91 ± 3.88#152.44 ± 0.89*

HemodynamicSBP (mmHg)124.31 ± 1.2287.51 ± 3.54###115.84 ± 1.08***
DBP (mmHg)91.41 ± 1.4467.72 ± 1.02###78.65 ± 1.32***
EDP (mmHg)14.91 ± 2.117.13 ± 1.02###18.28 ± 4.27***
MABP (mmHg)122.25 ± 4.3279.92 ± 0.12##98.65 ± 0.78

LV functionMax / (mmHg/s)3921.93 ± 322.342619.29 ± 80.41##3695.72 ± 287.95*
Min / (mmHg/s)−2513.14 ± 457.65−1694.52 ± 447.21#−2143.29 ± 398.47
Contractility index56.18 ± 5.6537.75 ± 3.18###43.52 ± 2.98***

Data are expressed as mean ± SEM () and analyzed by one-way ANOVA followed by post hoc Dunnett’s test. *;***; ns: nonsignificant compared with diabetic group; #; ##; ###; ns: nonsignificant compared with nondiabetic group.