A miRNA-Driven Inference Model to Construct Potential Drug-Disease Associations for Drug Repositioning

Table 4

Prediction results of associated diseases for the drug bilobalide.

Drug	Common miRNA(s)	Disease	P value	Evidence
Bilobalide	hsa-miR-148a hsa-miR-27a; hsa-miR-27b hsa-miR-328; hsa-miR-451 hsa-miR-519c	Breast neoplasms	5.51E − 04	CTD confirmed
Bilobalide	hsa-miR-27a hsa-miR-27b; hsa-miR-328 hsa-miR-451	Carcinoma, non-small-cell lung	0.00178	CTD confirmed
Bilobalide	hsa-miR-148a hsa-miR-27b; hsa-miR-328 hsa-miR-451	Colorectal neoplasms	0.00908	CTD confirmed
Bilobalide	hsa-miR-148a hsa-miR-27a; hsa-miR-27b	Endometrial neoplasms	0.00408
Bilobalide	hsa-miR-148a hsa-miR-27a; hsa-miR-27b hsa-miR-328; hsa-miR-451 hsa-miR-519c	Gastric neoplasms	3.61E − 05
Bilobalide	hsa-miR-148a hsa-miR-451	Gastrointestinal neoplasms	0.0149
Bilobalide	hsa-miR-148a hsa-miR-27b; hsa-miR-451	Glioblastoma	0.0212
Bilobalide	hsa-miR-27a hsa-miR-451; hsa-miR-519c	Neoplasms	0.0294	CTD confirmed
Bilobalide	hsa-miR-148a hsa-miR-27a; hsa-miR-451	Pancreatic neoplasms	0.0278	CTD confirmed
Bilobalide	hsa-miR-148a hsa-miR-27a; hsa-miR-27b	Prostatic neoplasms	0.0286	CTD confirmed
Bilobalide	hsa-miR-148a hsa-miR-27a; hsa-miR-27b	Carcinoma, squamous cell	0.0106	CTD confirmed
Bilobalide	hsa-miR-148a hsa-miR-27a; hsa-miR-27b	Adenoviridae infections	0.0110
Bilobalide	hsa-miR-27a hsa-miR-27b; hsa-miR-451	Glioma	0.00433
Bilobalide	hsa-miR-328 hsa-miR-451	Myocardial infarction	0.0184	CTD confirmed
Bilobalide	hsa-miR-148a hsa-miR-27b	Leukemia, lymphocytic, chronic, B-cell	0.0389
Bilobalide	hsa-miR-451	Leukemia, myelogenous, chronic	0.0228
Bilobalide	hsa-miR-27b	Oral lichen planus	0.0303
Bilobalide	hsa-miR-148a	Amyloidosis	0.0228
Bilobalide	hsa-miR-148a	Fibrodysplasia ossificans progressiva	0.00764
Bilobalide	hsa-miR-27a	Lymphoma, extranodal NK-T-Cell	0.0152	CTD confirmed
Bilobalide	hsa-miR-27b	Cryptosporidium	0.0303
Bilobalide	hsa-miR-27a	Heart diseases	0.0303
Bilobalide	hsa-miR-27b	Dyslipidemia	0.00764
Bilobalide	hsa-miR-328	Myopia	0.00764
Bilobalide	hsa-miR-451	Erythropoiesis	0.00764
Bilobalide	hsa-miR-451	Leukemia, myelogenous, chronic, BCR-ABL positive	0.00764