R990G Polymorphism of Calcium Sensing Receptor Gene Is Associated with High Parathyroid Hormone Levels in Subjects with Vitamin D Deficiency: A Cross-Sectional Study

Table 4

Association of R990G:A986S haplotype with plasma iPTH, serum calcium, and serum 25OHD levels.

R990G:A986S	Frequency	Mean plasma iPTH difference; pg/mL (95% CI)	value	Mean serum calcium difference; mg/dL (95% CI)	value	Mean serum 25OHD difference (95% CI)	value
A:G	0.68	0.00	—	0.00	—	0.00	—
A:T	0.17	15.3; (−7.06–37.64)	0.18	0.1; (−0.07–0.26)	0.25	−1.5; (−3.8–0.77)	0.2
G:G	0.12	49.4; (11.57–61.83)	0.0049	−0.11; (−0.29–0.08)	0.26	−0.9; (−3.63–1.69)	0.48
G:T	0.03	36.7; (0.48–98.4)	0.05	−0.51; (−0.88–−0.14)	0.0079	−1.6; (−7.24–3.96)	0.57

Haplotype association with quantitative variables was computed using online SNPstats software taking A:G haplotype as a reference.
value < 0.05 was considered statistically significant.