NOD-Like Receptor Signaling in Cholesteatoma

Figure 4

Bioinformatical network analysis for NOD. Proteins are the nodes and the edges are protein activations/inactivations, such as phosphorylation and dephosphorylation across a set of proteins. The network reveals an upregulation of NOD2, NLRC4, and PYCARD and the downstream molecules IRAK1 and cFLAR (red), whereas SMAD3 seems to be downregulated (green). TLR2, TLR4, NOD1, and RIPK2 were not significantly altered (black). RIPK2 displayed a remarkable network with many genes involved in the inflammatory and apoptotic process within the cholesteatoma. samples; means ± SEM; .