Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

Table 1

Inclusion and exclusion criteria for the study participants. Criteria for eligibility in the Valencia Study on Diabetic Retinopathy (VSDR).

Inclusion	Males and females, aged >25 years and <80 years with type 2 diabetes for 12 months (at least)
	Insulin naïve
	Healthy individuals as controls
	No ocular or systemic diseases or aggressive treatments and no ocular surgery or laser for 12 months (at least); no other oral supplements with antioxidants and/or omega 3 fatty acids
	Provided written informed consent before any related activities commence
	Participants able to attend the visits and to follow the study guidelines
Exclusion	Males and females, aged <25 years and >80 years
	Insulin dependent patients
	Ocular or systemic diseases or aggressive treatments and/or previous ocular surgery or laser
	Antioxidant and/or omega 3 fatty acids supplements
	No acceptance for the study participation and/or not signing the informed consent
	Participants unable to attend the visits or to follow the study guidelines