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BioMed Research International
Volume 2015 (2015), Article ID 413751, 8 pages
http://dx.doi.org/10.1155/2015/413751
Research Article

Sepsis and AKI in Clinical Emergency Room Patients: The Role of Urinary NGAL

São Paulo State University (UNESP), Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil

Received 4 February 2015; Revised 19 May 2015; Accepted 21 May 2015

Academic Editor: Anastasia Kotanidou

Copyright © 2015 Hong Si Nga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Few studies have investigated the predictive properties of urinary (u) NGAL as an AKI marker in septic population. Objectives. This study evaluated the efficacy of uNGAL as predictor of AKI and death in septic patients admitted to the clinical emergency room (ER). Methodology. We prospectively studied patients with sepsis admitted to the ER. Urine was analyzed for NGAL within the first 24 hours after admission (classified as NGAL1), between 24 and 48 h (NGAL2), and at moment of AKI diagnosis (NGAL3). Results. Among 168 septic patients admitted to ER, 72% developed AKI. The uNGAL and its relationship with creatinine (Cr) were high in septic patients but statistically higher in those with sepsis and AKI. The uNGAL1 and uNGAL2, as well as uNGAL1/uCr1 and uNGAL2/uCr2, were good predictors for AKI (AUC-ROC 0.73, 0.70, 0.77, and 0.84, resp.). The uNGAL1 and uNGAL1/uCr1 were poor predictors for death (AUC-ROC 0.66 and 0.68, resp.), whereas uNGAL2 and uNGAL2/uCr2 were better predictors (AUC-ROC 0.70 and 0.81, resp.). Conclusion. The uNGAL is highly sensitive but nonspecific predictor of AKI and death in septic patients admitted into ER.