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BioMed Research International
Volume 2015, Article ID 413897, 10 pages
http://dx.doi.org/10.1155/2015/413897
Research Article

The Oncofetal Protein IMP3: A Novel Grading Tool and Predictor of Poor Clinical Outcome in Human Gliomas

1Division of Pathology, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, 20122 Milan, Italy
2Division of Pathology, Ospedale Sant’Anna, 22020 Como, Italy
3Division of Neurosurgery, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, 20122 Milan, Italy
4Department of Pathophysiology and Organ Transplant, University of Milan, 20122 Milan, Italy
5Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy

Received 23 September 2014; Revised 14 November 2014; Accepted 14 November 2014

Academic Editor: Nader Pouratian

Copyright © 2015 Alessandro Del Gobbo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Morphologic criteria illustrated in WHO guidelines are the most significant prognostic factor in human gliomas, but novel biomarkers are needed to identify patients with a poorer outcome. The present study examined the expression of the oncofetal protein IMP3 in a series of 135 patients affected by high-grade (grade III and IV) gliomas, correlating the results with proliferative activity, molecular parameters, and clinical and follow-up data. Overall, IMP3 expression was higher in glioblastomas (68%) than in grade III tumors (20%, ), and IMP3-positive high-grade gliomas showed a shorter overall and disease-free survival than negative ones ( and , resp.). IMP3 expression was significantly associated with the absence of mutations of IDH1 gene () and with the unmethylated phenotype of MGMT in high-grade gliomas (). High Ki67 levels were correlated with better prognosis in glioblastomas but IMP3 expression was not correlated with the proliferation index. These findings confirm the role of IMP3 as a marker of poor outcome, also in consideration of its association with IDH1 wild-type phenotype and MGMT unmethylated status. The data suggest that IMP3 staining could identify a subgroup of patients with poor prognosis and at risk of recurrence in high-grade gliomas.