The Oncofetal Protein IMP3: A Novel Grading Tool and Predictor of Poor Clinical Outcome in Human Gliomas

Figure 3

In silico analysis of IMP3 levels in human gliomas. The Rembrandt database was queried for IMP3 gene (IGF2BP3) expression in gliomas and in nonneoplastic counterparts (a) or for correlation of IMP3 overexpression with GBM patients’ prognosis ( GBM patients) (b). Kaplan-Meier survival curves were generated for GBM with unchanged IMP3 expression (fold-change 0.8–1.2, intermediate group, ) or overexpression (fold-change ≥5, high group, ). values are from log-rank test. Astr.: astrocytoma; OD: oligodendroglioma; normal: nonneoplastic brain parenchyma; GBM: glioblastoma.

(a)

(b)