Successive Intramuscular Boosting with IFN-Alpha Protects Mycobacterium bovis BCG-Vaccinated Mice against M. lepraemurium Infection

Figure 3

Representative results of the inflammatory area in the granuloma and oxide nitric production in serum of the infected mice with M. lepraemurium. Eight weeks after intradermal MLM infection, mice were sacrificed and skin lesions were obtained. Inducible Nitric Oxide Synthase (iNOS, red), NT (green), Gr-1 (White) expression were measured by immunofluorescence (a). Graphics of the inflammatory area (a) and nitric oxide concentration in serum of uninfected, MLM-infected, BCG-vaccinate, IFM-alpha-boosted and BCG-vaccinated/IFN-alpha boosted mice (b) are shown. A difference of was considered significant.

(a)

(b)

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