Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway

Figure 7

Effects of BRACs on the interactions of HER2 with RAF, MEK, ERK, and JNK. MCF-10A, MCF-7, and MDA-MB-453 cells were treated with BRACs (0 or 200 μg/mL) for 24 h. Cell lysates were collected and immunoprecipitated with anti-HER2 antibody and then immunoblotted with antibodies against HER2, RAF/phosphorylated (p)-RAF, MEK/p-MEK/p-ERK, and JNK/p-JNK.