Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway

<div>Effects of black rice anthocyanins (BRACs) extract and small interfering RNA (siRNA) on the activation of RAF/MAPK in MDA-MB-453 cells. MDA-MB-453 cells were treated with BRACs (0 or 200 <i>μ</i>g/mL) with or without<i> raf</i>-,<i> mek</i>-, or<i> jnk</i>-siRNAs for 24 h. Phosphorylation of (a) RAF, (b) MEK1, and (c) JNK was determined using immunoblotting (IB). Expression of <i>β</i>-actin served as an internal control.</div>

BioMed Research International

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Figure 9

Figure 9: Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway 