Diversity and Global Distribution of IncL/M Plasmids Enabling Horizontal Dissemination of β-Lactam Resistance Genes among the Enterobacteriaceae

Figure 2

Comparative analyses of IncL/M plasmids. (a) Phylogenetic tree based on the 20 core genes of the IncL/M plasmids. (b) Comparative genomic analysis of the IncL/M plasmids (sequence annotations of several plasmids have been manually corrected; the distinguished genes are shown by arrows on the linear maps: red: bla genes; yellow: other AR genes). The gray-shaded areas connect DNA regions of different plasmids with at least 68% nucleotide sequence identity. (c–k) Comparison of the antibiotic resistance gene contents of the IncL/M plasmids: (c) β-lactam resistance genes; (d) aminoglycoside resistance genes; (e) macrolide resistance genes; (f) quinolone resistance genes; (g) trimethoprim resistance genes; (h) sulfonamide resistance genes; (i) bleomycin resistance genes; (j) chloramphenicol resistance genes; (k) tetracycline resistance genes.