Diversity and Global Distribution of IncL/M Plasmids Enabling Horizontal Dissemination of β-Lactam Resistance Genes among the Enterobacteriaceae

Table 2

Unique genes identified within IncL/M plasmids.

Plasmid name	Number of singletons	Singleton gene/locus tag [possible function]
pACM1	1	dfrA1/D733_p1025 [dihydrofolate reductase]
pARM26	0	—
pCTX-M3	3	dfrA12/pCTX-M3_084 [dihydrofolate reductase]; orfF/pCTX-M3_085 [integron gene cassette, hypothetical protein]; aadA2/pCTX-M3_086 [streptomycin 3′-adenyltransferase]
pCTX-M360	0	—
pE71T	0	—
pEl1573	5	mphA/D727_p1024 [macrolide phosphorylase]; mrx/D727_p1026 [protein of unknown function, required for MphA expression]; mphR(A)/D727_p1027 [transcriptional regulator for macrolide phosphorylase gene mph(A)]; catB3/D727_p1035 [chloramphenicol acetyltransferase]; blaIMP-4/D727_p1038 [IMP-4 metallo--lactamase]
pEL60	2	orf8/pEL60p08 [hypothetical protein]; kfrA/pEL60p09 [plasmid maintenance protein KfrA]
pENT-d0d	0	—
pENT-e56	0	—
pFOX-7a	9	blaFOX-7/D647_p51042 [FOX-7 -lactamase]; mdrL/D647_p51043 [major facilitator transporter]; lysR/D647_p51044 [LysR family transcriptional regulator]; tnpA/D647_p51045 [transposase of IS1634-family insertion sequence]; tnpA/D647_p51046 [transposase of ISApu1 (IS4 family/ISH8 group)]; D647_p51047 [hypothetical protein]; tnpA/D647_p51048 [transposase of ISApu2 (IS4 family/ISH8 group)]; istA/D647_p51052 [IstA protein of IS1326 (IS21 family)]; istB/D647_p51053 [IstB protein of IS1326 (IS21 family)]
pIGT15	0	—
pJEG011	5	strA/D647_p23045 [streptomycin phosphotransferase A]; strB/D647_p23040 [streptomycin phosphotransferase B]; aphA6/D647_p23043 [aminoglycoside 3′-phosphotransferase]; tnpA/D647_p23042 [transposase of IS1-family insertion sequence]; blaCTX-M-14/D647_p23049 [extended-spectrum -lactamase]
pKOI-34	7	arsR [arsenical resistance operon repressor]; arsD [arsenical resistance operon transacting repressor]; arsA [arsenical pump-driving ATPase]; arsB [arsenic efflux pump protein]; arsC [arsenate reductase]; ycgA [arsenical pump-driving ATPase]; [IMP-34 metallo--lactamase]
pKPN-068	0	—
pKPoxa-48N1	0	—
pNDM-HK	1	insL/D616_p59011 [transposase of IS4 family/IS231 group insertion sequence]
pNDM-OM	0	—
pNE1280	8	istB/KPC4_0043 [IstB protein of IS21-family insertion sequence]; blaKPC-4/KPC4_0045 [β-lactamase]; tnpA/KPC4_0047 [transposase]; KPC4_0049 [hypothetical protein]; KPC4_0051 [hypothetical protein]; KPC4_0053 [hypothetical protein]; rom/KPC4_0055 [Rop family protein]; exc1/KPC4_0057 [exclusion protein 1]
pOXA-48a	0	—
R830b	15	tniQ/D739_p1005 [transposase helper protein TniQ]; D739_p1006 [resolvase/integrase]; D739_p1010 [organomercurial lyase]; D739_p1020 [putative reverse transcriptase]; D739_p1024 [hypothetical protein]; D739_p1025 [Il-IS_2, transposase]; D739_p1026 [lipoprotein signal peptidase]; D739_p1027 [cobalt-zinc-cadmium resistance protein CzcD]; D739_p1028 [Cd(II)/Pb(II)-responsive transcriptional regulator]; D739_p1029 [hypothetical protein]; D739_p1107 [resolvase]; D739_p1108 [S-formylglutathione hydrolase]; D739_p1109 [glyoxalase]; D739_p1110 [S-(hydroxymethyl)glutathione dehydrogenase]; D739_p1111 [uncharacterized protein YaiN in formaldehyde detoxification operon]