Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines

Figure 3

Effects of antiresistin RNA oligo on lipid deposition in the liver and hepatic steatosis. Sections of liver from chow fed mice and HFD fed mice treated with a control oligo or antiresistin oligo were stained with Hematoxylin/Eosin (a). Bottom left corner shows enlarged views of inset image. The arrows show hepatic steatosis and Oil Red O (b) to visualize lipid droplets. The hepatic steatosis grade was based on the percentage of steatotic hepatocytes in the H&E-stained liver sections (c). Hepatic tissue triglyceride levels (d) in all groups of mice. Data are mean ± SE. . versus chow fed mice; versus HF-Con-oligo mice.

(a) Hematoxylin/Eosin

(b) Oil Red O

(c)

(d)