A Kinetic-Model-Based Approach to Identify Malfunctioning Components in Signal Transduction Pathways from Artificial Clinical Data

Figure 9

The patterns shown in NF-κB profiles upon the down/upregulation of single reactions/preexisting proteins: (a) upregulation of each reaction rate constant by 100 times, (b) downregulation of each reaction rate constant by 0.0001 times, (c) upregulation of each preexisting molecule by 10 times, and (d) downregulation of each preexisting molecule by 0.01 times. The red curves represent representative abnormal patterns studied in this work, while the green curves are obtained for the normal condition. The magenta curve in (d) is a representative medium level change profile that is used to generate clinical data for Table 10.

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