Table 3: Analysis of combination drug effects of TCEE with cisplatin or doxorubicin in Hep3B and HepJ5 cells. Combination drug index (CDI) was analyzed on cell viability data obtained from Figure 3 by using the CalcuSyn software. CDI < 1 indicated a synergistic effect, CDI = 1 indicated an additive effect, and CDI > 1 indicated an antagonistic effect.

Combination drug index
Hep3BHepJ5
Plus 0.2 mg/mL TCEEPlus 0.5 mg/mL TCEE

Cisplatin (μM)10.520.75
20.590.77
40.640.96
60.611.08
80.481.03
100.470.88
201.160.55

Doxorubicin (μM)0.50.611.39
10.771.04
1.50.740.71
20.380.79
30.320.72
40.580.58
50.670.78