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BioMed Research International
Volume 2015, Article ID 415289, 18 pages
Review Article

Bone Regeneration from PLGA Micro-Nanoparticles

1Department of Oral Surgery and Implant Dentistry, University of Granada, 18011 Granada, Spain
2Department of Pathology, School of Medicine and IBIMER, University of Granada, 18012 Granada, Spain
3Biocolloid and Fluid Physics Group, Department of Applied Physics, University of Granada, 18071 Granada, Spain
4Department of Applied Physics II, University of Málaga, 29071 Málaga, Spain

Received 27 March 2015; Accepted 4 June 2015

Academic Editor: Hojae Bae

Copyright © 2015 Inmaculada Ortega-Oller et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Poly-lactic-co-glycolic acid (PLGA) is one of the most widely used synthetic polymers for development of delivery systems for drugs and therapeutic biomolecules and as component of tissue engineering applications. Its properties and versatility allow it to be a reference polymer in manufacturing of nano- and microparticles to encapsulate and deliver a wide variety of hydrophobic and hydrophilic molecules. It additionally facilitates and extends its use to encapsulate biomolecules such as proteins or nucleic acids that can be released in a controlled way. This review focuses on the use of nano/microparticles of PLGA as a delivery system of one of the most commonly used growth factors in bone tissue engineering, the bone morphogenetic protein 2 (BMP2). Thus, all the needed requirements to reach a controlled delivery of BMP2 using PLGA particles as a main component have been examined. The problems and solutions for the adequate development of this system with a great potential in cell differentiation and proliferation processes under a bone regenerative point of view are discussed.