Inhibition of P-Selectin and PSGL-1 Using Humanized Monoclonal Antibodies Increases the Sensitivity of Multiple Myeloma Cells to Bortezomib

Figure 3

P-selectin and PSGL-1 affect proliferation of MM cells cocultured with endothelial and stromal cells in vitro. The effect of SelG1 antibody (10 μg/mL) used on endothelial and stromal cells and SelK2 (10 μg/mL) used on H929 cells on MM cell proliferation, with or without bortezomib (5 nM) treatment, analyzed by flow cytometry and normalized to untreated cells. Values were considered significant for .

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