A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening

Table 1

Antimicrobial activity of the screening extract from F31/11 broth measured as an endpoint in microdilution method, that is, the highest dilution that inhibits 80% of test strain growth.

Microorganism	Medium	Active dilution
L100 S. aureus ATCC 6538P	EBH/S	>1 : 64
L3751 S. aureus L-form	EBH/S	<1 : 4
L100 S. aureus ATCC 6538P	EBH/S + β-lactamase cocktail	1 : 64
L100 S. aureus ATCC 6538P	EBH/S + Ac-Lys-D-Ala-D-Ala	1 : 64
L1400 S. aureus MRSA	MHB	1 : 64
L49 S. pyogenes	THB	>1 : 64
L559 E. faecalis	MHB	1 : 8
L560 E. faecalis Van A	MHB	1 : 16
L47 E. coli	MHB	<1 : 4
L145 C. albicans	RPMI	<1 : 4