A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening

Table 3

Retention time and typical UV and mass signals of actagardine and planosporicin and of major microbisporicin congeners in the LC-UV-MS system described in Section 2. Mass signals are reported in Dalton. and signals indicate, respectively, lambda (max) and lambda (shoulder).

ANTIBIOTIC	M	r.t. (min)	[M + 2H]^2+	[M − 2H]^2−	[M + H]^+	UV nm; ( and )
Actagardine	1889	10.6	944.5	943.5	1890	227, 282
Microbisporicin A1	2246	12.2	1125.3	1123.4	2247	226, 267
Microbisporicin A2	2230	11.7	1117.2	1115.3	2231	225, 267
Microbisporicin 1768α	2214	12.8	1108.5	—	2215	223, 270
Microbisporicin 1768β	2180	9.6	1091	—	2181	223, 270
Planosporicin	2196	8.7	1099.7	1097.7	2197	225, 279, 288
F31/11 broth extract	2230	11.7	1117.2	1115.2	2231	225, 267
F31/11 mycelium extract	2246	12.2	1125.3	1123.4	2247	226, 267