BioMed Research International

Research Article

Drug Susceptibility Testing of 31 Antimicrobial Agents on Rapidly Growing Mycobacteria Isolates from China

Table 2

MIC (μg/mL) results of the antimicrobial susceptibility tests for five rapidly growing reference mycobacteria.


Sp.	RFP	INH	EMB	SM	AM	KN	CPM	TOB	OF	CIP	LEV	SPA	MXF	LNZ	CLO	SMZ

M. abscessus	64	>256	32	16	1	2	*0.5*	8	4	2	1	2	1	4	*0.06*	32
M. chelonae	>256	>256	128	32	4	16	16	2	32	4	16	16	4	8	*0.25*	64
M. fortuitum	128	64	256	32	*0.25*	4	*<0.03*	16	*0.13*	*0.03*	*0.03*	*<0.03*	*<0.03*	8	*0.03*	2
M. septicum	16	256	4	16	*0.13*	*0.5*	*<0.03*	1	*0.25*	*0.06*	*0.13*	*0.03*	*0.06*	1	*0.13*	1
M. neoaurum	1	>256	8	*0.5*	*0.5*	*0.06*	*<0.03*	*0.25*	*0.06*	*0.06*	*0.03*	*<0.03*	*<0.03*	*0.5*	*0.03*	*0.5*

Sp.	MIN	DOX	TIG	CLR	AZM	ROX	AMC	FOX	CMZ	MEM	RFT	RFB	DAP	THI	PASI

M. abscessus	8	32	4	*<0.03*	*<0.03*	*0.03*	>256	32	32	64	*0.13*	32	64	16	32
M. chelonae	64	>32	1	*0.06*	*0.5*	2	>256	128	*<0.25*	>256	*0.13*	32	32	>256	>256
M. fortuitum	8	*0.03*	*0.5*	1	2	4	>256	32	4	4	1	16	8	256	2
M. septicum	32	8	1	1	16	4	>256	128	1	16	*0.13*	*<0.03*	32	256	4
M. neoaurum	*0.03*	*0.06*	*0.03*	1	1	2	32	8	1	*0.5*	*0.06*	*0.13*	4	>256	64

Note : M. abscessus: ATCC19977; M. chelonae: ATCC35752; M. fortuitum: DSM44220; M. neoaurum: ATCC25795; and M. septicum: DSM44393.
Note : INH: isoniazid; RFP: rifampicin; EMB: ethambutol; SM: streptomycin; AM: amikacin; KN: kanamycin; CPM: capreomycin; TOB: tobramycin; OF: ofloxacin; CIP: ciprofloxacin; LEV: levofloxacin; SPA: sparfloxacin; MXF: moxifloxacin; LNZ: linezolid; CLO: clofazimine; SMZ: sulfamethoxazole; CLR: clarithromycin; AZM: azithromycin; ROX: roxithromycin; MIN: minocycline; DOX: doxycycline; TIG: tigecycline; AMC: Amoxicillin-clavulanic Acid; FOX: cefoxitin; CMZ: cefmetazole; MEM: meropenem; RPT: rifapentine; RBT: rifabutin; DAP: dapsone; THI: thioacetazone; PASI: pasiniazid.
Note : Bold, italic values indicate drug susceptibility. Values shown in bold indicate moderate drug susceptibility.