Analysis of Anaphylactic Shock Caused by 17 Types of Traditional Chinese Medicine Injections Used to Treat Cardiovascular and Cerebrovascular Diseases

Table 1

Patients who suffered anaphylactic shock after being treated with 17 types of traditional Chinese medicine injections for cardiovascular and cerebrovascular diseases.

Serial number	Chinese herbal injections	Constituents	Number of cases	Distributions of ages^*	Sex	Mode of delivery	Onset of symptoms	Distributions of onset^*	Timely rescue	Number of deaths
1	Shenmai injection	(1) Red ginseng; (2) Ophiopogon japonicus	39	0/22/11/6	26 F, 13 M	36IVI^*, 3IMI^*	10 s–1 h	8/25/6/0/0	Yes	0
2	Ciwujia injection	Ciwujia stem and leaf extracts	33	0/11/14/8	15 F, 18 M	33IVI	3 min–2.5 h	1/15/13/3/1	Yes	0
3	Salvia miltiorrhiza injection	Salvia miltiorrhiza extract	9	0/5/2/2	3 F, 6 M	9IVI	1 min–30 min	2/4/3/0/0	Yes	0
4	Tanshinone IIA sodium; sulfonate injection	Salvia miltiorrhiza extract; main components: Two terpene quinone compounds	5	0/0/1/4	3 F, 2 M	5IVI	2 min–30 min	0/1/4/0/0	Yes	0
5	Dan Hong injection	(1) Salvia miltiorrhiza extract; (2) Safflower extract	4	0/2/0/2	3 F, 1 M	4IVI	1 min–40 min	0/3/1/0/0	Yes	0
6	Breviscapine injection	Erigeron breviscapus extract	11	0/2/4/5	3 F, 8 M	11IVI	3 min–2 h	0/2/6/3/0	Yes	0
7	Erigeron injection	Erigeron breviscapus extract: phenolic constituents; Main component: wild Baicalin, total caffeic acid ester	6	0/0/0/6	4 F, 2 M	6IVI	10 min–1.5 h	0/1/4/1/0	Yes	0
8	Compound Danshen injection	(1) Salvia miltiorrhiza extract; (2) Dalbergia extract	53	0/19/18/16	23 F, 30 M	53IVI	10 s–2 h	5/30/15/3/0	Yes	5 death, 1 fetal death
9	Puerarin injection	(1) Puerarin extract; (2) Propylene glycol, water for injection	23	0/1/11/11	8 F, 15 M	23IVI	2 min–2 h	1/2/18/2/0	Yes	2
10	Safflower injection	Safflower extract; Main components: safflower yellow pigment, safflower quinone, glycoside, carthamin, new carthamin	27	0/7/10/11	15 F, 12 M	27IVI	2 min–1 h	1/16/10/0/0	Yes	0
11	Mailuoning injection	Honeysuckle, Achyranthes root, Dendrobium, Xuan Can	64	1/19/15/29	30 F, 34 M	64IVI	10 s–50 min	11/40/13/0/0	Yes	2
12	Shengmai injection	Red ginseng, Ophiopogon japonicus, Schisandra chinensis	16	0/2/5/9	7 F, 9 M	16IVI	10 s–30 min	3/10/3/0/0	Yes	0
13	Shuxuetong injection	Leech and earthworm	6	0/1/3/2	4 F, 2 M	6IVI	5 min–1.5 h	0/3/2/1/0	Yes	0
14	Xingnaojing injection	Musk, borneol, turmeric, Gardenia	17	2/7/3/5	4 F, 13 M	17IVI	3 s–45 min	1/12/4/0/0	Yes	0
15	Xuebijing injection	Extracts: safflower, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Salviae miltiorrhizae, Radix Angelicae sinensis Main component: safflor yellow A	12	2/7/2/1	7 F, 5 M	12IVI	2 min–10 min	0/12/0/0/0	Yes	0
16	Xuesaitong injection	Total saponins of three-seven byproducts, main components: Ginsenoside Rb1, Ginsenoside Rg1, three-seven, Ginsenoside R1	21	0/3/5/13	13 F, 8 M	20IVI, 1IMI	2 min–1.5 h	1/11/8/1/0	Yes	0
17	Xueshuantong injection	Three-seven root extracts, main components: Ginsenoside Rg1, Ginsenoside Rb1	4	0/0/2/2	1 F, 3 M	4IVI	3 min–1 h	0/2/2/0/0	Yes	0
	Total		350	5/108/106/132	169 F, 181 M			34/189/112/14/1

Distributions of ages: number of children (≤18 years)/number of youth (19–45 years)/number of middle-aged (46–59 years)/number of aged cases (≥60 years).
^*Distributions of onset: within 1 min/between 1 min to 10 mins/between 11 mins to 60 mins/between 61 mins to 120 mins/over 120 mins.
IVI: intravenous injection.
IMI: intramuscular injection.
The references of the cases are in the support material.