EMT-Inducing Molecular Factors in Gynecological Cancers

Table 1

Factors involved in EMT of gynecological cancers.

	Cervical cancer	Ovarian cancer	Endometrial cancer	Vulvar cancer	Vaginal cancer
Transcriptional regulators	Snail/Slug/Smuc; Zeb1/Zeb2; Twist1/Twist2; E47	Snail; Zeb1/2; Twist1; KLF4; ETV5; HMGA2	Snail/Slug Zeb1; Twist1/Twist2; KLF17; ETV5; HMGA2	Snail/Slug; Twist2
Growth factors	TGF-β; EGF	TGF-β; EGF /HB-EGF; VEGF; HGF; FGF	TGF-β; EGF; VEGF; IGF1
Oncogenes	HPV16 E6/E7; Sam68; AEG1; FTS	PIK3CA; AKT2	BMI-1
Tumor; suppressors	Klotho; SFRPs	P53; SFRPs; RASAL2	P53
miRNAs	miR-200 family; miR-155; miR-361-5p	miR-200 family; miR-181; miR-20a; miR-214	miR-200 family; miR-155; miR-130
Other molecular factors	β1-integrin receptors; MMPs 7/9; IL6; RhoC; Gelsolin; TBLR1; TACC3; KCC3; EphB2; Nogo-B; TNF-α	β1-integrin receptors; MMP 9; IL6; RhoC; MUC4/16; ET-1; BMP4; CCR7; TG2; PAK1; MTA1; Sema3E; Gb2; FN1	ERα; TrkB; PR	ERα/β