LINE-1 Methylation Patterns as a Predictor of Postmolar Gestational Trophoblastic Neoplasia

Table 1

Association of clinicopathologic variables and LINE-1 methylation level.

LINE-1 level (mean ± SD)	Parameters
	^mC	^mC^mC	PM	^mC^uC	^uC^mC	^uC^uC
Age (years)
≤40
>40
value	0.484	0.296	0.086	0.169	<0.001	0.094
Pretreatment hCG level (mIU/mL)^*
<100,000
≥100,000
value	0.173	0.133	0.005	0.544	0.234	0.004
Pathological diagnosis
Complete hydatidiform mole
Partial hydatidiform mole
value	0.939	0.565	0.463	0.137	0.158	0.748
Metastasis
No metastasis
Metastasis
value	0.304	0.578	0.806	0.660	0.860	0.415

PM = percentage of LINE-1 partial methylation.
^mC^uC, ^uC^mC = percentage of LINE-1 partially methylated loci.
^mC^mC = percentage of LINE-1 hypermethylated loci number.
^uC^uC = percentage of LINE-1 hypomethylated loci number.
^mC = percentage of LINE-1 methylation.
^*Incomplete data for 15 patients.