LINE-1 Methylation Patterns as a Predictor of Postmolar Gestational Trophoblastic Neoplasia

Table 2

Diagnostic power of the methylation levels combined with hCG.

Diagnostic tools	PM	^mC^uC	^uC^mC	^mC^uC + ^uC^mC	^mC^uC + ^uC^mC + hCG^*
Sensitivity	60.9%	88.1%	71.1%	69.0%	60.0%
Specificity	84.5%	55.3%	81.6%	85.4%	92.2%
PPV	64.4%	44.5%	61.2%	65.9%	77.4%
NPV	87.0%	91.9%	87.5%	87.1%	83.8%
Accuracy	80.0%	64.8%	78.6%	80.7%	82.3%

hCG-pretreatment hCG: positive if ≥100,000 IU/mL.
PM-partial methylation: positive if ≤44.0%, ^mC^uC-partially methylated loci: positive if ≥40.9%, ^uC^mC-partially methylated loci: positive if ≤10.7%, and ^*incomplete data in 15 patients.