Research Article
The Effect of Formulation Excipients and Thermal Treatment on the Release Properties of Lisinopril Spheres and Tablets
Table 1
Composition of all formulations and targeted hardness of the tablets.
| | Formula name | Lisinopril (wt%) | Compritol (wt%) | Avicel pH-101 (wt%) | Lactose (wt%) | Dibasic CaPO4 (wt%) | Distilled water (mL) | Targeted hardness (kP) |
| | LCAD | 10 | 30 | 30 | 0 | 30 | 370 | 6.5–9 | | LCA60 | 10 | 30 | 60 | 0 | 0 | 700 | 4 | | LCAL | 10 | 30 | 30 | 30 | 0 | 400 | 7–9 | | LC50A40 | 10 | 50 | 40 | 0 | 0 | 560 | 4–5 |
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