Research Article
The Effect of Formulation Excipients and Thermal Treatment on the Release Properties of Lisinopril Spheres and Tablets
Table 2
Physicochemical properties of the tablets before and after thermal treatment.
| | Parameters | LCAL | LCAD | LCA60 | LC50A40 | | Before | After | Before | After | Before | After | Before | After |
| | Weight (mg) | 422.9 ± 6.1 | 404.7 ± 2.5 | 420.8 ± 1.5 | 397.1 ± 2.0 | 421.3 ± 1.7 | 420.8 ± 3.7 | 418.8 ± 3.9 | 418.7 ± 6.1 | | Thickness (mm) | 2.99 ± 0.03 | 3.00 ± 0.01 | 2.74 ± 0.01 | 2.77 ± 0.02 | 2.98 ± 0.01 | 3.02 ± 0.02 | 3.47 ± 0.04 | 3.58 ± 0.07 | | Diameter (mm) | 12.01 ± 0.03 | 12.06 ± 0.03 | 12.03 ± 0.05 | 12.05 ± 0.07 | 12.04 ± 0.05 | 12.14 ± 0.04 | 12.02 ± 0.02 | 12.09 ± 0.02 | | Hardness (kP) | 8.43 ± 0.43 | 7.04 ± 0.38 | 7.35 ± 0.46 | 6.56 ± 0.46 | 2.8 ± 0.31 | 4.02 ± 0.34 | 4.09 ± 0.62 | 4.80 ± 0.53 | | Disintegration (min) | 60 ± 0.00 | 60 ± 0.00 | 60 ± 0.00 | 60 ± 0.00 | 13.00 ± 3.09 | 31.00 ± 10.52 | 60 ± 0.00 | 47.60 ± 11.07 | | Friability (%) | 0.05 | 0.00 | 0.06 | 0.00 | 11.77 | 0.07 | 0.00 | 0.00 |
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; data are expressed as mean ± standard deviation. Formulation parameters were evaluated before and after thermal treatment.
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